concept

DNA damage

Also known as: DNA damage accumulation

Facts (18)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 7 facts

referenceThe role of damage to DNA and other macromolecules in aging is discussed in the 2009 paper 'Does damage to DNA and other macromolecules play a role in aging? If so, how?' published in The Journals of Gerontology: Series A.

claimNicotinamide mononucleotide (NMN) protects skin cells, such as keratinocytes, from UV radiation-caused DNA damage by enhancing DNA repair, which contributes to reversing skin ageing.

claimNAD+ acts as a hydride-accepting coenzyme involved in DNA repair and the preservation of genome stability, and increased levels of NAD+ reduce DNA damage.

measurementNicotinamide mononucleotide (NMN) alleviates retina damage, reduces DNA damage by 50%, and eliminates senescent cells (SCs) in age-related macular degeneration models.

referenceCell senescence, DNA damage, and metabolism are interconnected, as reviewed by Shmulevich and Krizhanovsky in a 2021 article in Antioxidants & Redox Signaling.

claimThe DNA repair response in stem cells declines with ageing, leading to the loss of stem cell properties, DNA damage-caused cellular senescence, and organ atrophy.

referenceDNA damage and repair mechanisms are connected to the aging process, as discussed in a 2016 review by Pan et al. in the International Journal of Molecular Sciences.

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 5 facts

claimThe hyper-sensitivity of pluripotent stem cells to DNA damage is termed 'mitochondrial priming', referring to the fact that their cell death pathways are specific to mitochondria-triggered apoptosis rather than receptor-mediated apoptosis.

claimMitochondrial priming allows pluripotent stem cells to rapidly undergo cell death following DNA damage.

claimMaynard et al. (2008) found that human embryonic stem cells possess enhanced repair capabilities for multiple forms of DNA damage, as published in 'Human embryonic stem cells have enhanced repair of multiple forms of DNA damage' in Stem Cells.

claimAdult stem cells are generally considered more resistant to cell death than pluripotent stem cells, though they may still undergo cell death in response to DNA damage.

claimCancer cells exhibit a radically different sensitivity to cell death compared to stem cells, as they are capable of surviving in the presence of high levels of reactive oxygen species (ROS) and DNA damage.

Integrating allostasis and emerging technologies to study complex ... nature.com Nature Nov 5, 2025 2 facts

claimDysregulation from allostatic load contributes to DNA damage, immune suppression, and chronic inflammation, which are hallmarks of tumor initiation, progression, and metastasis.

claimMetabolic and inflammatory dysregulation contributes to DNA damage, immune suppression, and chronic inflammation, which are hallmarks of tumor initiation, progression, and metastasis.

Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us Journal of Food Science & Nutrition 2 facts

referenceSilymarin protects epidermal keratinocytes from ultraviolet radiation-induced apoptosis and DNA damage by utilizing the nucleotide excision repair mechanism, as reported by Katiyar, Mantena, and Meeran in 2011.

claim2,3-dehydrosilybin reduces UV radiation-induced DNA damage, according to Li et al. [106].

Risk Factors: Chronic Inflammation - NCI - National Cancer Institute cancer.gov National Cancer Institute Apr 29, 2015 1 fact

claimChronic inflammation can result in DNA damage and lead to the development of cancer over time.

Hallmarks and mechanisms of cellular senescence in aging ... - Nature nature.com Nature Aug 4, 2025 1 fact

referenceSchumacher B, Garinis GA, and Hoeijmakers JH analyzed the relationship between DNA damage and aging in a 2008 article in Trends in Genetics.