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related 2.32 — strongly supporting 4 facts
The prefrontal cortex is the specific brain region being studied in nonhuman primates, as evidenced by the researchers performing recordings and electrical stimulation within this area in [1], [2], and [3], while also utilizing these subjects for cross-species comparative studies in [4].
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Protocol for testing global neuronal workspace and integrated ... journals.plos.org 4 facts
procedureThe researchers will manipulate prefrontal cortex activity on a trial-to-trial basis using electrical stimulation in non-human primates and optogenetic silencing in mice.
procedureTo enable cross-species comparisons, the study protocol involves non-human primates (NHPs) and mice viewing or listening to supra-threshold visual or auditory stimuli for variable durations in a go-nogo task that controls for report confounds, while recording neuronal responses from visual, auditory, posterior parietal, and/or prefrontal cortical areas using Neuropixels electrodes.
procedureIn non-human primates, the researchers will replace Neuropixels probes in the prefrontal cortex (areas 45/46) with linear electrode arrays (e.g., 24-contacts, 200 µm spacing) for stimulation across cortical layers after completing simultaneous recordings from PFC and posterior cortical sites.
procedureThe researchers will manipulate prefrontal cortex (PFC) activity from 0–0.5 seconds after stimulus onset in non-human primates and mice for irrelevant stimuli, using a single stimulus duration of 0.5 seconds.