inflammation ↔ chemokines

Relations (1)

related 0.50 — strongly supporting 5 facts

Chemokines are integral to the process of inflammation, as they are released by platelets [1], innate immune cells [2], and eosinophils [3] to recruit leukocytes [4] and facilitate the activation of immune cells at injury sites [5].

Facts (5)

Sources

The Role of Immune Cells in Inflammation jmolpat.com Lukas Freund · Journal of Molecular Pathophysiology 3 facts

claimEosinophils produce cytokines and chemokines that recruit additional immune cells to the site of inflammation.

claimNeutrophils are among the first immune cells to arrive at the site of inflammation, attracted by chemokines produced by activated macrophages and other immune cells.

claimUpon activation of Pattern Recognition Receptors (PRRs), innate immune cells produce pro-inflammatory cytokines and chemokines that attract and activate additional immune cells to the site of inflammation.

Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov National Library of Medicine 2 facts

claimCirculating platelets contribute to inflammation through platelet aggregation, thrombus formation, and degranulation, which releases chemokines and inflammatory mediators.

claimOnce circulating leukocytes enter a local injury site, they are activated by cytokines and chemokines secreted by macrophages and dendritic cells, subsequently releasing their own cytokines and mediators of inflammation.