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inflammation ↔ TNF-α

Relations (1)

related 0.20 — supporting 2 facts

TNF-α is directly linked to inflammation as it is a key cytokine produced during inflammation that activates endothelial cells and recruits immune cells [1], and treatments for low-grade inflammation reduce circulating TNF-α levels [2].

Facts (2)

Sources
The Role of Immune Cells in Inflammation jmolpat.com Lukas Freund · Journal of Molecular Pathophysiology 1 fact
claimTumor Necrosis Factor-alpha (TNF-α) is a key cytokine produced during inflammation that activates endothelial cells lining blood vessels, leading to increased vascular permeability and the recruitment of additional immune cells to the site of inflammation.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov National Library of Medicine 1 fact
claimMetformin is used to treat type II diabetic patients with dyslipidemia and low-grade inflammation, and it reduces circulating TNF-alpha, IL-1beta, CRP, and fibrinogen.