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Relations (1)
related 3.58 — strongly supporting 9 facts
Inflammation and cellular senescence are intrinsically linked as both drivers and consequences of tissue dysfunction, aging, and disease, as evidenced by their co-occurrence in chronic conditions like AMD and CKD [1], [2]. Furthermore, senescent cells actively promote inflammation through the secretion of SASP factors [3], while inflammatory environments can conversely degrade stem cell function and promote senescence [4], [5].
Facts (9)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com 7 facts
claimInjured tissue environments, characterized by inflammation, immune impairment, hypoxic stress, and poor blood supply, degrade stem cell function, promote cellular senescence, and result in low survival rates for transplanted stem cells in vivo.
referenceInflammation, epigenetics, and metabolism converge to influence cell senescence and aging, as described by Zhu et al. in a 2021 Signal Transduction and Targeted Therapy paper.
claimCellular senescence can cause inflammation and metabolic disturbances associated with obesity, and the elimination of senescent cells with senolytic interventions may help improve obesity clinically.
claimCellular senescence, stress-induced premature ageing, the senescence-associated secretory phenotype (SASP), oxidative stress, and inflammation contribute to the development of chronic kidney disease (CKD).
claimMolecular pathways involving cellular senescence, oxidative stress, insulin signaling, autophagy, and inflammation are linked to the deterioration of cardiovascular homeostasis.
claimIn chronic wounds, the interaction between senescent cells and the extracellular matrix is a barrier to healing because senescent cells produce Senescence-Associated Secretory Phenotype (SASP) factors and Reactive Oxygen Species (ROS), which increase matrix proteolysis, cause inflammation, impair vascular endothelial cells, and create a microenvironment that accelerates further cellular senescence.
claimAge-related macular degeneration (AMD) is primarily attributed to oxidative stress, cellular senescence, and inflammation.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 2 facts
claimThe article "Cellular senescence: from homeostasis to pathological implications and therapeutic strategies" addresses the topics of cellular senescence, cancer, m6A RNA methylation, aging, longevity, and inflammation.
referenceThe article 'Redox regulation of SIRT1 in inflammation and cellular senescence' published in Free Radical Biology and Medicine in 2013 (61:95–110) explores the redox regulation of SIRT1 during inflammation and cellular senescence.