Knowledge Tree
Cellular senescence
Also known as: cell senescence
Facts (46)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 26 facts
claimRen et al. (2022) found that nicotinamide mononucleotide ameliorates cellular senescence and inflammation caused by sodium iodate in retinal pigment epithelium (RPE) cells.
claimInjured tissue environments, characterized by inflammation, immune impairment, hypoxic stress, and poor blood supply, degrade stem cell function, promote cellular senescence, and result in low survival rates for transplanted stem cells in vivo.
referenceInflammation, epigenetics, and metabolism converge to influence cell senescence and aging, as described by Zhu et al. in a 2021 Signal Transduction and Targeted Therapy paper.
claimStrategies for tissue regeneration include the elimination of senescent cells with senolytics, exogenous stem cell transplantation to replenish the stem cell pool, the use of extracellular vesicles (EVs) and their engineered derivatives to alleviate cellular senescence, and the application of wound inflammatory and chemical compounds to rejuvenate stem cells.
referenceCellular senescence is defined and its future research paths are explored in the 2019 paper 'Cellular senescence: defining a path forward' published in Cell.
claimSenolytics, which kill senescent cells and stop the bystander effects of the senescence-associated secretory phenotype (SASP), are a potential treatment for age-related macular degeneration (AMD) due to the role of cellular senescence in its pathogenesis.
claimApproaches for treating diabetes by targeting senescent β cells include novel drugs for antagonizing β cell senescence, regulating metabolic burden to protect β cell function, inhibiting islet inflammation, in vivo reprogramming for β cell regeneration, and epigenetic modifications to rejuvenate senescent β cells.
claimCellular senescence can cause inflammation and metabolic disturbances associated with obesity, and the elimination of senescent cells with senolytic interventions may help improve obesity clinically.
referenceTargeting cellular senescence prevents age-related bone loss in mice, as demonstrated by Chandra et al. in Nature Medicine (2017).
claimOgrodnik, Salmonowicz, and Gladyshev integrated cellular senescence with the concept of damage accumulation in aging, specifically regarding the relevance for clearance of senescent cells, in a 2019 Aging Cell article.
referenceMechanisms and therapeutic implications of cellular senescence in osteoarthritis were reviewed by Zheng et al. in Nature Reviews Rheumatology (2021).
claimCellular senescence contributes significantly to ageing and ageing-related diseases, suggesting that targeting cellular senescence may allow for the reversal of ageing.
referencePalmer et al. (2015) identified cellular senescence as a therapeutic opportunity in type 2 diabetes.
claimCellular senescence, stress-induced premature ageing, the senescence-associated secretory phenotype (SASP), oxidative stress, and inflammation contribute to the development of chronic kidney disease (CKD).
referenceTGF-beta signaling is involved in cellular senescence and aging-related pathology.
referenceRoy et al. provided a blueprint for characterizing senescence in a 2020 article in Cell.
referenceCellular senescence and its potential role in tumor promotion and aging are examined in the 2016 paper 'Cellular senescence and tumor promotion: Is aging the key?' published in Biochimica et Biophysica Acta.
claimMolecular pathways involving cellular senescence, oxidative stress, insulin signaling, autophagy, and inflammation are linked to the deterioration of cardiovascular homeostasis.
claimMusi, N. et al. established that tau protein aggregation is associated with cellular senescence in the brain.
referenceCell senescence, DNA damage, and metabolism are interconnected, as reviewed by Shmulevich and Krizhanovsky in a 2021 article in Antioxidants & Redox Signaling.
referenceLiu, R. M. discusses aging, cellular senescence, and Alzheimer’s disease in the International Journal of Molecular Sciences.
claimCellular senescence contributes to Alzheimer’s disease pathophysiology through mechanisms involving telomerase deficiency, telomere shortening, accumulation of β-amyloid, tauopathy, and oxidative stress.
claimCasella et al. identified a transcriptome signature of cellular senescence in a 2019 study published in Nucleic Acids Research.
claimThe DNA repair response in stem cells declines with ageing, leading to the loss of stem cell properties, DNA damage-caused cellular senescence, and organ atrophy.
claimIn chronic wounds, the interaction between senescent cells and the extracellular matrix is a barrier to healing because senescent cells produce Senescence-Associated Secretory Phenotype (SASP) factors and Reactive Oxygen Species (ROS), which increase matrix proteolysis, cause inflammation, impair vascular endothelial cells, and create a microenvironment that accelerates further cellular senescence.
claimAge-related macular degeneration (AMD) is primarily attributed to oxidative stress, cellular senescence, and inflammation.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 14 facts
referenceThe article 'Underlying mechanisms and treatment of cellular senescence-induced biological barrier interruption and related diseases' published in Aging and Disease in 2024 (15:612–39) examines the mechanisms and treatments for biological barrier interruption caused by cellular senescence.
claimThe article titled "Cellular senescence: from homeostasis to pathological implications and therapeutic strategies" was published in the journal Frontiers in Immunology on February 3, 2025.
referenceThe article 'Sirtuins and cellular senescence in patients with idiopathic pulmonary fibrosis and systemic autoimmune disorders' published in Drugs in 2024 (84:491–501) investigates sirtuins and cellular senescence in patients with idiopathic pulmonary fibrosis and systemic autoimmune disorders.
claimThe article "Cellular senescence: from homeostasis to pathological implications and therapeutic strategies" addresses the topics of cellular senescence, cancer, m6A RNA methylation, aging, longevity, and inflammation.
claimCellular senescence plays a role in the tumor microenvironment.
referenceThe review article 'Targeting cell senescence and senolytics: novel interventions for age-related endocrine dysfunction' was published in Endocrine Reviews in 2024 (Volume 45, pages 655–75).
claimThe p53 protein plays a role in the regulation of cellular senescence.
referenceThe article 'Redox regulation of SIRT1 in inflammation and cellular senescence' published in Free Radical Biology and Medicine in 2013 (61:95–110) explores the redox regulation of SIRT1 during inflammation and cellular senescence.
referenceZhang C, Chen L, Xie C, Wang F, Wang J, Zhou H et al. reported in The EMBO Journal (2024) that YTHDC1 delays cellular senescence and pulmonary fibrosis by activating ATR in an m6A-independent manner.
claimHypoxia plays a role in cellular senescence.
referenceCellular senescence and senolytics are being developed as clinical interventions, as outlined by Chaib et al. in Nature Medicine (2022).
claimThe protein hnRNP A1 antagonizes cellular senescence and the senescence-associated secretory phenotype by regulating the stability of SIRT1 mRNA.
claimCellular senescence is a factor in the pathology of glioma.
referenceChen et al. (2024) reported in Oncogene that METTL3 promotes cellular senescence of colorectal cancer via modulation of CDKN2B transcription and mRNA stability.
Chronic inflammation in the etiology of disease across the life span nature.com Dec 5, 2019 2 facts
claimCellular senescence is a factor in aging and cancer, as detailed in a 2013 review in the Annual Review of Physiology.
claimCellular senescence and the senescent secretory phenotype are linked to age-related chronic diseases, according to a 2014 review in Current Opinion in Clinical Nutrition and Metabolic Care.
The hallmarks of aging as a conceptual framework for health and ... frontiersin.org Jan 15, 2024 2 facts
Hallmarks and mechanisms of cellular senescence in aging ... - Nature nature.com Aug 4, 2025 1 fact
referenceDavalli P, Mitic T, Caporali A, Lauriola A, and D'Arca D published 'ROS, cell senescence, and novel molecular mechanisms in aging and age-related diseases' in Oxidative Medicine and Cellular Longevity in 2016.
Deep insight into cytokine storm: from pathogenesis to treatment nature.com Apr 16, 2025 1 fact
referenceType 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging.