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Relations (1)
related 3.46 — strongly supporting 10 facts
Macrophages are a primary source of the pro-inflammatory cytokine TNF-α, as evidenced by their role in producing it during immune responses [1], [2], and [3]. Additionally, TNF-α acts as a signaling molecule that can subsequently activate macrophages [4], [5] or bind to their receptors to induce cell activation [2].
Facts (10)
Sources
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 4 facts
claimTumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine produced by macrophages that binds to CD120a and CD120b receptors on macrophages to induce phagocyte cell activation and endotoxic shock.
claimThe release of IFN-γ or TNF-α during a cytokine storm leads to the activation of macrophages, dendritic cells, other immune cells, and endothelial cells.
claimB cells and macrophages produce IL-38, which inhibits IL-1, IL-6, IL-17, IL-22, and TNF.
procedureIn the pathogenesis of a cytokine storm, the activation of T cells or the lysis of immune cells induces the release of IFN-γ or TNF-α, which subsequently activates macrophages, dendritic cells, other immune cells, and endothelial cells.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 3 facts
claimIn response to foreign or self-antigens, tissue immune cells like macrophages and dendritic cells release cytokines such as IL-1 and TNF-α.
claimCytokines released by macrophages and dendritic cells (such as IL-1 and TNF-α) induce endothelial cells at the injury site to release Selectins and Integrins, which stimulate the chemotaxis and diapedesis of circulating leukocytes.
claimIn response to foreign or self-antigens, tissue immune cells like macrophages and dendritic cells release cytokines such as IL-1 and TNF-α, which induce endothelial cells at the injury site to release Selectins and Integrins to stimulate leukocyte chemotaxis and diapedesis.
3. The Innate Immune System - Immunopaedia immunopaedia.org.za 2 facts
claimCytokines produced by macrophages have systemic effects: IL-1 induces fever, TNF-alpha causes wasting (cachexia), IL-6 induces liver production of acute phase proteins, and IL-3 increases neutrophil maturation and release from bone marrow.
claimMacrophages produce major cytokines including TNF-alpha, IL-1 beta, IL-6, IL-8, and IL-33.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 1 fact
measurementIn a randomized, double-blind, placebo-controlled trial involving 46 healthy older adults (ages 55 to 75 years), daily supplementation with 720 mg of EPA and 280 mg of DHA for 12 weeks had no effect on the numbers of neutrophils, monocytes, or macrophages, nor did it affect respiratory burst or the production of cytokines TNF-α, IL-1β, and IL-6.