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anxiety ↔ ketamine

Relations (1)

related 2.00 — strongly supporting 3 facts

Ketamine is related to anxiety as it is investigated as a therapeutic intervention for the condition in clinical studies [1], [2], while also being identified as a substance that can induce anxiety-like behavioral changes in experimental models [3].

Facts (3)

Sources
The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org Frontiers in Psychiatry 2 facts
referenceHassan et al. (2022) performed a retrospective study on the safety, effectiveness, and tolerability of sublingual ketamine for the treatment of depression and anxiety in an at-home, off-label setting.
referenceHull et al. (2022) conducted a large, prospective, open-label effectiveness trial which found that at-home, sublingual ketamine telehealth is a safe and effective treatment for moderate to severe anxiety and depression.
Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer 1 fact
claimKetamine treatment in adolescent mice induces hyperlocomotion, anxiety, ataxia, stereotyped behaviour, mitochondrial damage, and morphological abnormalities in hippocampal and cortical cells, alongside increased dopamine and glutamate levels in the cortex and hippocampus.