Knowledge Tree
Relations (1)
related 2.00 — strongly supporting 3 facts
Interleukin-8 is a pro-inflammatory cytokine that specifically targets neutrophils to facilitate chemotaxis as described in [1], and it is also identified as a downstream chemokine activated by the recruitment of neutrophils in [2], while [3] discusses the role of IL-8 in immune cell recruitment during SARS-CoV-2 infection.
Facts (3)
Sources
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 3 facts
claimIn the context of SARS-CoV-2 infection, the cytokines IL-12 and IL-8 enhance IFN-γ production, which attracts monocytes and T lymphocytes, but not neutrophils, to induce apoptosis and eliminate infected cells.
referenceIL-8 is classified as a pro-inflammatory cytokine, is produced by macrophages, binds to the IL-8R receptor, targets neutrophils, and functions in chemotaxis for neutrophils and T cells.
referenceIL-17 is classified as a pro-inflammatory cytokine, is produced by Th17 cells, binds to the IL-17R receptor, targets monocytes and neutrophils, and functions in recruiting monocytes and neutrophils to the site of infection and activating downstream cytokines and chemokines including IL-1, IL-6, IL-8, IL-21, TNF-beta, and MCP-1.