apnea-hypopnea index ↔ hypertension

Relations (1)

related 2.58 — strongly supporting 5 facts

The apnea-hypopnea index is a clinical metric used to quantify the severity of obstructive sleep apnea, which exhibits a dose-response relationship with hypertension as evidenced by [1], [2], and [3]. Furthermore, studies such as the Sleep Heart Health Study utilize the apnea-hypopnea index to evaluate the independent risk and correlation between sleep-disordered breathing and hypertension [4], [5].

Facts (5)

Sources

Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov Colten HR, Altevogt BM · National Academies Press 5 facts

measurementAn observational cohort study of 1,022 individuals found that obstructive sleep apnea syndrome (defined as an apnea-hypopnea index of 5 or higher) significantly increased the risk of stroke or death from any cause, independent of other risk factors such as hypertension.

referenceThe Sleep Heart Health Study is a community-based multicenter study of more than 6,000 middle-aged and older adults that measured the apnea-hypopnea index via polysomnography and found that the likelihood of hypertension was greater at higher apnea-hypopnea index levels.

claimThere is a dose-response relationship between Obstructive Sleep Apnea and hypertension, where a higher apnea-hypopnea index correlates with a greater increase in blood pressure.

claimThe Sleep Heart Health Study determined the apnea-hypopnea index using polysomnography and adjusted for confounding factors, including hypertension, finding that the association between obstructive sleep apnea and cardiovascular disease persisted even after adjusting for hypertension.

claimA causal association between Obstructive Sleep Apnea and hypertension is supported by a dose-response relationship where higher apnea-hypopnea index levels correlate with greater increases in blood pressure, as reported by Peppard et al. (2000) and Nieto et al. (2000).