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related 2.81 — strongly supporting 6 facts
The apnea-hypopnea index is a clinical metric used to diagnose sleep-disordered breathing, which is strongly associated with an increased risk of stroke as evidenced by observational studies [1], [2]. Furthermore, a high apnea-hypopnea index is frequently observed in patients who have already suffered a stroke [3], [4], and is statistically linked to a higher incidence of stroke in longitudinal research [5], [6].
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Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov 6 facts
measurement60 to 70 percent of individuals who have suffered a stroke exhibit sleep-disordered breathing with an apnea-hypopnea index of 10 or greater.
measurementAn observational cohort study of 1,022 individuals found that obstructive sleep apnea syndrome (defined as an apnea-hypopnea index of 5 or higher) significantly increased the risk of stroke or death from any cause, independent of other risk factors such as hypertension.
measurementIn a 10-year observational study, patients with untreated severe obstructive sleep apnea (apnea-hypopnea index greater than 30) had a higher incidence of fatal and nonfatal cardiovascular events—including myocardial infarction, stroke, and coronary artery bypass surgery—compared to patients with similar severity who received CPAP treatment.
measurementStudies by Dyken et al. (1996) and Bassetti et al. (1996) found that 60 to 70 percent of individuals who have suffered a stroke exhibit sleep-disordered breathing with an apnea-hypopnea index of 10 or greater.
measurementIn the Sleep Heart Health Study, participants in the highest apnea-hypopnea index quartile had an adjusted odds ratio of 1.58 (95% CI, 1.02–2.46) for stroke.
measurementThe Sleep Heart Health Study, a cross-sectional study of nearly 6,500 participants, found that individuals in the highest apnea-hypopnea index quartile (index greater than 11) were 42 percent more likely to self-report cardiovascular disease, including coronary heart disease, heart failure, or stroke, compared to those in the lowest quartile (adjusted OR = 1.42, 95% CI, 1.13–1.78).