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granulosa cells ↔ progesterone

Relations (1)

related 2.32 — strongly supporting 4 facts

Granulosa cells are the site of progesterone synthesis and secretion, as they are stimulated by FSH and LH to produce this hormone during the follicular and luteinization phases as described in [1], [2], [3], and [4].

Facts (4)

Sources
The Normal Menstrual Cycle and the Control of Ovulation - NCBI - NIH ncbi.nlm.nih.gov Feingold KR, Adler RA, Ahmed SF · National Center for Biotechnology Information 3 facts
claimThe luteinizing hormone (LH) surge stimulates the luteinization of granulosa cells and the synthesis of progesterone, which is responsible for the midcycle follicle-stimulating hormone (FSH) surge.
claimIn the presence of estradiol, follicle-stimulating hormone (FSH) stimulates the formation of luteinizing hormone (LH) receptors on granulosa cells, allowing for the secretion of small quantities of progesterone and 17-hydroxyprogesterone (17-OHP), which may exert a positive feedback on the estrogen-primed pituitary to augment LH release.
claimThe luteinizing hormone (LH) surge stimulates the luteinization of granulosa cells and the synthesis of progesterone, which is responsible for the midcycle follicle-stimulating hormone (FSH) surge.
Unknown source 1 fact
claimProgesterone and 17-hydroxyprogesterone (17-OHP) secreted by granulosa cells may exert a positive feedback on the estrogen-primed pituitary to augment luteinizing hormone (LH) release.