Knowledge Tree
Relations (1)
related 2.00 — strongly supporting 3 facts
Psilocybin directly decreases activity in the posterior cingulate cortex (PCC), as shown in studies by Kometer et al. [1] and Carhart-Harris et al. [2], and contributes to reduced oscillatory activity and functional coupling in the Default Mode Network involving PCC [3].
Facts (3)
Sources
The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org 3 facts
measurementKometer et al. (2015) reported that psilocybin causes a decrease in posterior cingulate cortex (PCC) activity, a decrease in ventromedial prefrontal cortex (vmPFC) activity, and decreased connectivity in the parahippocampal gyrus (PH) and retrosplenial cortex (RSC).
measurementCarhart-Harris et al. (2012) reported that psilocybin causes a decrease in posterior cingulate cortex (PCC) activity and reduced connectivity in the default mode network (DMN) and precuneus.
claimThe reduction in oscillatory activity and power in the Default Mode Network caused by psilocybin results from decreased functional coupling between the frontal cortex and the medial temporal lobe components of the Default Mode Network, as well as between the medial prefrontal cortex and the posterior cingulate cortex.