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Relations (1)
related 3.32 — strongly supporting 9 facts
Macrophages are a primary source of the pro-inflammatory cytokine IL-1, as evidenced by their role in releasing it in response to antigens [1], [2], and [3]. Furthermore, macrophages produce IL-1 to induce systemic effects like fever [4], while IL-1 signaling can also influence the recruitment of macrophages to sites of infection [5].
Facts (9)
Sources
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 4 facts
claimBinding events at the site of infection increase local levels of IL-1β and IL-8, which recruit macrophages and monocytes to remove apoptotic cell fragments.
claimIL-1β is a potent pro-inflammatory cytokine induced primarily by lymphocytes, macrophages, and monocytes in response to microbial molecules.
claimB cells and macrophages produce IL-38, which inhibits IL-1, IL-6, IL-17, IL-22, and TNF.
referenceIL-1 is classified as a pro-inflammatory cytokine, is produced by macrophages, B cells, and dendritic cells, binds to the CD121a receptor, targets B cells, NK cells, and T cells, and functions in pyrogenic activity, inflammation, cell proliferation, differentiation, and bone marrow cell proliferation.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 3 facts
claimIn response to foreign or self-antigens, tissue immune cells like macrophages and dendritic cells release cytokines such as IL-1 and TNF-α.
claimCytokines released by macrophages and dendritic cells (such as IL-1 and TNF-α) induce endothelial cells at the injury site to release Selectins and Integrins, which stimulate the chemotaxis and diapedesis of circulating leukocytes.
claimIn response to foreign or self-antigens, tissue immune cells like macrophages and dendritic cells release cytokines such as IL-1 and TNF-α, which induce endothelial cells at the injury site to release Selectins and Integrins to stimulate leukocyte chemotaxis and diapedesis.
3. The Innate Immune System - Immunopaedia immunopaedia.org.za 1 fact
claimCytokines produced by macrophages have systemic effects: IL-1 induces fever, TNF-alpha causes wasting (cachexia), IL-6 induces liver production of acute phase proteins, and IL-3 increases neutrophil maturation and release from bone marrow.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 1 fact
measurementIn a randomized, double-blind, placebo-controlled trial involving 46 healthy older adults (ages 55 to 75 years), daily supplementation with 720 mg of EPA and 280 mg of DHA for 12 weeks had no effect on the numbers of neutrophils, monocytes, or macrophages, nor did it affect respiratory burst or the production of cytokines TNF-α, IL-1β, and IL-6.