Knowledge Tree
IL-1
Facts (21)
Sources
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 12 facts
claimThe key factors identified in pathologies involving a cytokine storm are TNF-α, interferons, IL-1β, MCP-1 (CCL2), and IL-6.
claimViral infection leads to the expression of pattern recognition receptors (PPR) and toll-like receptors (TLRs), which enhance the expression of IL-1β.
claimIL-1β stimulates CD4+ cells and differentiates them into Th17 cells.
claimBinding events at the site of infection increase local levels of IL-1β and IL-8, which recruit macrophages and monocytes to remove apoptotic cell fragments.
claimPro-inflammatory cytokines include IL-1, IL-2, IL-12, IL-17, IL-18, IFN-γ, and TNF-α.
claimIL-1β is a potent pro-inflammatory cytokine induced primarily by lymphocytes, macrophages, and monocytes in response to microbial molecules.
claimB cells and macrophages produce IL-38, which inhibits IL-1, IL-6, IL-17, IL-22, and TNF.
measurementIL-1Ra expression must increase up to 1,000-fold to efficiently inhibit or suppress the expression of IL-1β.
referenceThe article 'Induction of Pro-Inflammatory Cytokines (IL-1 and IL-6) and Lung Inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): Anti-Inflammatory Strategies' was published in the Journal of Biological Regulators and Homeostatic Agents in 2020 (Volume 34, pages 327-331).
referenceIL-1 is classified as a pro-inflammatory cytokine, is produced by macrophages, B cells, and dendritic cells, binds to the CD121a receptor, targets B cells, NK cells, and T cells, and functions in pyrogenic activity, inflammation, cell proliferation, differentiation, and bone marrow cell proliferation.
referenceIL-17 is classified as a pro-inflammatory cytokine, is produced by Th17 cells, binds to the IL-17R receptor, targets monocytes and neutrophils, and functions in recruiting monocytes and neutrophils to the site of infection and activating downstream cytokines and chemokines including IL-1, IL-6, IL-8, IL-21, TNF-beta, and MCP-1.
claimIL-1, IL-6, and TNF-α are considered key pro-inflammatory cytokines.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 6 facts
claimNeutrophils destroy antigens through phagocytosis and the release of reactive oxygen species and cytokines, including IL-1, IL-6, and TNF-α.
claimIn response to foreign or self-antigens, tissue immune cells like macrophages and dendritic cells release cytokines such as IL-1 and TNF-α.
claimThe cytokines IL-1 and TNF-α induce injury-site endothelial cells to release Selectins and Integrins, which stimulate chemotaxis and diapedesis of circulating leukocytes.
claimCytokines released by macrophages and dendritic cells (such as IL-1 and TNF-α) induce endothelial cells at the injury site to release Selectins and Integrins, which stimulate the chemotaxis and diapedesis of circulating leukocytes.
claimIn response to foreign or self-antigens, tissue immune cells like macrophages and dendritic cells release cytokines such as IL-1 and TNF-α, which induce endothelial cells at the injury site to release Selectins and Integrins to stimulate leukocyte chemotaxis and diapedesis.
claimCherries and cherry juice consumption has been shown to be uricosuric and inhibitory for interleukin-1 (IL-1) in patients with gout.
Self-awareness, self-regulation, and self-transcendence (S-ART) frontiersin.org 1 fact
claimA decreased stress response and rapid return to physiological and emotional baseline involves physiological mediators including catecholamines (epinephrine and norepinephrine), glucocorticoids (cortisol), pituitary hormones (ACTH, prolactin, and growth hormones), and cytokines (IL-1, IL-6, and TNF-α).
3. The Innate Immune System - Immunopaedia immunopaedia.org.za 1 fact
claimCytokines produced by macrophages have systemic effects: IL-1 induces fever, TNF-alpha causes wasting (cachexia), IL-6 induces liver production of acute phase proteins, and IL-3 increases neutrophil maturation and release from bone marrow.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 1 fact
measurementIn a randomized, double-blind, placebo-controlled trial involving 46 healthy older adults (ages 55 to 75 years), daily supplementation with 720 mg of EPA and 280 mg of DHA for 12 weeks had no effect on the numbers of neutrophils, monocytes, or macrophages, nor did it affect respiratory burst or the production of cytokines TNF-α, IL-1β, and IL-6.