macrophages ↔ cytokine storm

Relations (1)

related 2.00 — strongly supporting 3 facts

Macrophages are central to the pathogenesis of a cytokine storm, as they are activated by cytokines like IFN-γ and TNF-α [1], [2] and subsequently produce IL-6 to sustain the positive feedback loop that drives the storm [3].

Facts (3)

Sources

Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com Thermo Fisher Scientific 3 facts

procedureMacrophages and endothelial cells produce large amounts of IL-6 after activation, which activates T cells and other immune cells, creating a positive feedback loop that results in a cytokine storm, the release of additional cytokines and chemokines, and the upregulation of acute phase proteins.

claimThe release of IFN-γ or TNF-α during a cytokine storm leads to the activation of macrophages, dendritic cells, other immune cells, and endothelial cells.

procedureIn the pathogenesis of a cytokine storm, the activation of T cells or the lysis of immune cells induces the release of IFN-γ or TNF-α, which subsequently activates macrophages, dendritic cells, other immune cells, and endothelial cells.