Knowledge Tree
Relations (1)
related 2.32 — strongly supporting 4 facts
Macrophages are directly linked to interleukin-8 because they are responsible for its production as a major cytokine [1] and as a pro-inflammatory mediator [2], while both are involved in the recruitment and regulation of immune cells at infection sites [3].
Facts (4)
Sources
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 3 facts
referenceIL-4 is classified as an adaptive immunity cytokine, is produced by Th cells, binds to the CD124 receptor, targets B cells, T cells, and macrophages, and functions in the proliferation of B and cytotoxic T cells, enhancement of MHC class II expression, and stimulation of IgG and IgE production.
claimBinding events at the site of infection increase local levels of IL-1β and IL-8, which recruit macrophages and monocytes to remove apoptotic cell fragments.
referenceIL-8 is classified as a pro-inflammatory cytokine, is produced by macrophages, binds to the IL-8R receptor, targets neutrophils, and functions in chemotaxis for neutrophils and T cells.
3. The Innate Immune System - Immunopaedia immunopaedia.org.za 1 fact
claimMacrophages produce major cytokines including TNF-alpha, IL-1 beta, IL-6, IL-8, and IL-33.