age-related diseases ↔ aging

Relations (1)

related 2.32 — strongly supporting 3 facts

Aging and age-related diseases are intrinsically linked through shared molecular mechanisms, such as mitochondrial DNA methylation [1], and are frequently studied together in clinical research regarding interventions like metformin [2] and the cell membrane theory of senescence [3]. Academic literature consistently categorizes these concepts as a unified field of study, as evidenced by comprehensive reviews on their molecular mechanisms and therapeutic implications [4].

Facts (3)

Sources

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 2 facts

referenceGuo J, Huang X, Dou L, Yan M, Shen T, Tang W, et al. authored 'Aging and aging-related diseases: from molecular mechanisms to interventions and treatments', published in Signal Transduction and Targeted Therapy in 2022 (7:391, doi: 10.1038/s41392-022-01251-0).

referenceThe article 'Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms' published in Theranostics in 2022 (12:2722–40) reviews the clinical applications and mechanisms of metformin regarding aging and aging-related diseases.

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature 1 fact

referenceThe 'Cell membrane theory of senescence' and the role of bioactive lipids in aging and associated diseases are discussed in the 2021 paper '“Cell membrane theory of senescence” and the role of bioactive lipids in aging, and aging associated diseases and their therapeutic implications' published in Biomolecules.