Knowledge Tree
age-related diseases
Also known as: age-related chronic diseases, age-related disorders, aging-related diseases, aging and age-related diseases, aging associated diseases, age-associated diseases
Facts (21)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 13 facts
referenceA single combination gene therapy can treat multiple age-related diseases, according to Chaib, Tchkonia, and Kirkland in the Proceedings of the National Academy of Sciences (2019).
referenceYin et al. (2021) investigated the roles of extracellular vesicles in the aging microenvironment and age-related diseases.
referenceRea, I. M. et al. published a study in 2018 titled 'Age and age-related diseases: role of inflammation triggers and cytokines' in Frontiers in Immunology, which examines the role of inflammation triggers and cytokines in aging and age-related diseases.
claimAltered intercellular communication is a hallmark of ageing, acting as a double-edged sword that contributes to both tissue homeostasis maintenance and age-related diseases.
referenceThe 'Cell membrane theory of senescence' and the role of bioactive lipids in aging and associated diseases are discussed in the 2021 paper '“Cell membrane theory of senescence” and the role of bioactive lipids in aging, and aging associated diseases and their therapeutic implications' published in Biomolecules.
claimCellular senescence contributes significantly to ageing and ageing-related diseases, suggesting that targeting cellular senescence may allow for the reversal of ageing.
referenceGrowth differentiation factor 11 is a potential rejuvenation factor involved in the regulation of age-related diseases.
claimThe systematic identification of gene networks, age-dependent changes in RNA, protein and metabolite molecules, and cellular interactions contributes to studies on stem cells in tissue repair and ageing-related diseases.
referenceSwer and Sharma (2021) reviewed the role of ATP-dependent chromatin remodelers in the processes of aging and age-related disorders.
claimHeterochronic parabiosis is used as an experimental system to examine systemic influences on lifespan, age-related diseases, and organismal aging.
referencePolyphenols can target the Wnt signaling pathway, with implications for aging and age-related diseases.
claimMetformin is considered a promising treatment for age-related diseases, such as degenerative skeletal diseases, by improving metabolism for cell rejuvenation.
claimClinical rejuvenation approaches to treat ageing-related diseases and reverse ageing are expected to develop significantly within the next two to three decades.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 5 facts
referenceGuo J, Huang X, Dou L, Yan M, Shen T, Tang W, et al. authored 'Aging and aging-related diseases: from molecular mechanisms to interventions and treatments', published in Signal Transduction and Targeted Therapy in 2022 (7:391, doi: 10.1038/s41392-022-01251-0).
referenceThe interplay between immunosenescence and age-related diseases is a subject of study, as reviewed by Barbé-Tuana et al. in a 2020 article in Seminars in Immunopathology.
referenceInsulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway, which impacts the aging process and age-related diseases, according to Salminen et al. (2021).
referenceThe article 'Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms' published in Theranostics in 2022 (12:2722–40) reviews the clinical applications and mechanisms of metformin regarding aging and aging-related diseases.
referenceAging and age-related diseases are addressed through various mechanisms and therapeutic strategies, as discussed by Li et al. in Biogerontology (2021).
Chronic inflammation in the etiology of disease across the life span nature.com Dec 5, 2019 2 facts
claimInflammaging is characterized as a new immune-metabolic viewpoint for understanding age-related diseases, as proposed in a 2018 article in Nature Reviews Endocrinology.
claimCellular senescence and the senescent secretory phenotype are linked to age-related chronic diseases, according to a 2014 review in Current Opinion in Clinical Nutrition and Metabolic Care.
Hallmarks and mechanisms of cellular senescence in aging ... - Nature nature.com Aug 4, 2025 1 fact
referenceDavalli P, Mitic T, Caporali A, Lauriola A, and D'Arca D published 'ROS, cell senescence, and novel molecular mechanisms in aging and age-related diseases' in Oxidative Medicine and Cellular Longevity in 2016.