Knowledge Tree
Relations (1)
related 2.58 — strongly supporting 5 facts
Ketamine is directly linked to antidepressant effects through clinical studies investigating its efficacy [1], the role of its metabolites in mediating these outcomes {fact:2, fact:3}, and the impact of concurrent medications or biological pathways on these effects {fact:4, fact:5}.
Facts (5)
Sources
Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com 3 facts
claimKetamine metabolites exhibit antidepressant actions that are independent of NMDAR inhibition, as reported in a 2016 study in Nature.
claimGSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine.
claim2R,6R-hydroxynorketamine (2R,6R-HNK), a metabolite of ketamine, may play a significant role in mediating antidepressant and neuroplastic effects.
The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org 2 facts
claimThe RAPID intravenous ketamine study, published by Feeney et al. in the Journal of Clinical Psychiatry in 2022, investigated the effect of concomitant benzodiazepines on the antidepressant effects of ketamine.
claimAndrashko et al. reported in European Neuropsychopharmacology in 2019 that concurrent benzodiazepines undermine the antidepressant effect of ketamine.