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antidepressant effects
Also known as: antidepressive effects, antidepressant-like effects, antidepressant properties
Facts (15)
Sources
Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Dec 19, 2024 12 facts
claimCannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects in research subjects.
referenceLi N et al. demonstrated that mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.
claimKetamine metabolites exhibit antidepressant actions that are independent of NMDAR inhibition, as reported in a 2016 study in Nature.
claimHarmine produces antidepressant-like effects via the restoration of astrocytic functions.
claimGSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine.
referenceFortunato JJ et al. demonstrated in a 2009 study that acute administration of harmine induces antidepressant-like effects and increases BDNF levels in the rat hippocampus.
claim2R,6R-hydroxynorketamine (2R,6R-HNK), a metabolite of ketamine, may play a significant role in mediating antidepressant and neuroplastic effects.
claimStudies on harmala alkaloids focus on their potential antidepressant effects, with in vivo research assessing hippocampal BDNF levels alongside behavioral methods.
referenceFortunato JJ et al. provided evidence of the antidepressant properties of the β-carboline harmine by observing behavioral and physiological parameters in a chronic mild stress model in rats, published in Brain Research Bulletin in 2010.
referenceFortunato JJ et al. found that chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in the rat hippocampus, as reported in a 2010 study in the Journal of Neural Transmission.
claimHarmala alkaloids, specifically harmine and harmaline, demonstrate antidepressant effects in animal models by enhancing neurogenesis.
claimFukumoto et al. (2019) demonstrated that activity-dependent brain-derived neurotrophic factor (BDNF) signaling is required for the antidepressant effects of (2R,6R)-hydroxynorketamine.
The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org 2 facts
claimThe RAPID intravenous ketamine study, published by Feeney et al. in the Journal of Clinical Psychiatry in 2022, investigated the effect of concomitant benzodiazepines on the antidepressant effects of ketamine.
claimAndrashko et al. reported in European Neuropsychopharmacology in 2019 that concurrent benzodiazepines undermine the antidepressant effect of ketamine.
Psychedelics, Sociality, and Human Evolution frontiersin.org 1 fact
claimA 2016 systematic review of clinical trials published in the previous 25 years found that ayahuasca, psilocybin, and lysergic acid diethylamide (LSD) demonstrate antidepressive, anxiolytic, and antiaddictive effects.