NMDA receptor antagonists ↔ ketamine

Relations (1)

related 2.32 — strongly supporting 4 facts

Ketamine is classified as an NMDA receptor antagonist, as evidenced by its identification as one of the most studied drugs in this class [1] and its recognition as the only NMDA antagonist currently used as a medical treatment [2]. Furthermore, research frequently compares ketamine's specific pharmacological properties to other NMDA antagonists [3] and distinguishes its effects from non-antagonist metabolites [4].

Facts (4)

Sources

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer 3 facts

claim2R,6R-hydroxynorketamine (2R,6R-HNK) does not act as an NMDAR antagonist and lacks the dissociative side effects typically associated with ketamine.

claimKetamine is currently the only NMDA antagonist recognized as a medical treatment.

claimKetamine and phencyclidine (PCP) are synthetic drugs originally discovered at the Parke-Davis Research Center and are among the most studied NMDA antagonists.

Psychedelics, Sociality, and Human Evolution frontiersin.org Frontiers 1 fact

claimThe NMDA antagonist ketamine and the 5-HT agonist psilocybin produce dissociable effects on the structural encoding of emotional face expressions.