NMDA receptor antagonists

Also known as: NMDA antagonist, NMDA receptor antagonists, NMDA antagonists

Facts (10)

Sources

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 7 facts

claimThe systematic review categorized psychedelics into five main groups: CB1 agonists, NMDA antagonists, harmala alkaloids, tryptamines, and entactogens.

referenceLi N et al. demonstrated that mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.

measurementIn the sample of 51 original articles reporting in vivo experiments, the most commonly used psychedelics were cannabinoid agonists (29.4%), NMDA antagonists (27.4%), and tryptamines (17.6%).

claimKetamine is currently the only NMDA antagonist recognized as a medical treatment.

claimThe neurotrophic hypothesis of depression posits that synaptogenesis plays a role in the therapeutic actions of NMDA receptor antagonists.

claimKetamine and phencyclidine (PCP) are synthetic drugs originally discovered at the Parke-Davis Research Center and are among the most studied NMDA antagonists.

referenceB. Pochwat et al. reviewed NMDA antagonists under investigation for the treatment of major depressive disorder in a 2014 article published in Expert Opinion on Investigational Drugs.

Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org Johns Hopkins Center for Psychedelic and Consciousness Research 1 fact

claimDextromethorphan, which acts as an NMDA antagonist, produces effects similar to classic hallucinogens when administered in high doses.

Psychedelics, Sociality, and Human Evolution frontiersin.org Frontiers 1 fact

claimThe NMDA antagonist ketamine and the 5-HT agonist psilocybin produce dissociable effects on the structural encoding of emotional face expressions.

The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org Frontiers in Psychiatry 1 fact

claimA 1998 study by Tsuda, Suzuki, and Misawa published in Brain Research found that NMDA receptor antagonists potently suppress spontaneous withdrawal signs induced by the discontinuation of long-term diazepam treatment in Fischer 344 rats.