Knowledge Tree
Relations (1)
related 0.50 — strongly supporting 5 facts
Inflammation and pro-inflammatory cytokines are intrinsically linked, as persistent inflammation triggers increased release of pro-inflammatory cytokines [1], innate immune cells produce them at the site of inflammation [2], and their production decreases as inflammation subsides [3], while they actively trigger, heighten, and promote inflammation {fact:4,5}.
Facts (5)
Sources
The Role of Immune Cells in Inflammation jmolpat.com 2 facts
claimAs the acute phase of inflammation subsides, the production of pro-inflammatory cytokines decreases, and the influx of immune cells into the affected tissue diminishes.
claimUpon activation of Pattern Recognition Receptors (PRRs), innate immune cells produce pro-inflammatory cytokines and chemokines that attract and activate additional immune cells to the site of inflammation.
Healthy vs. Infected Wounds: A Clinician's Guide - Net Health nethealth.com 1 fact
claimPersistent inflammation in infected wounds leads to an increased release of pro-inflammatory cytokines that can damage healthy tissue, excessive redness and swelling that hinders nutrient and oxygen delivery, and impaired migration of fibroblasts and other cells essential for tissue repair.
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 1 fact
claimPro-inflammatory cytokines promote inflammation, while anti-inflammatory cytokines reduce inflammation and support healing by opposing the actions of pro-inflammatory cytokines.
What are Cytokines? Types & Function - Cleveland Clinic my.clevelandclinic.org 1 fact
claimPro-inflammatory cytokines trigger or heighten inflammation to coordinate the immune response against attackers like germs.