Knowledge Tree
Relations (1)
related 2.58 — strongly supporting 5 facts
Neutrophils are directly targeted and recruited by pro-inflammatory cytokines such as IL-8 and IL-17 as described in [1] and [2], and they are also producers of pro-inflammatory cytokines like IFN-α as noted in [3]. Furthermore, [4] and [5] establish that neutrophils are recruited to infection sites and proliferate in response to the release of pro-inflammatory cytokines.
Facts (5)
Sources
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 3 facts
referenceIL-8 is classified as a pro-inflammatory cytokine, is produced by macrophages, binds to the IL-8R receptor, targets neutrophils, and functions in chemotaxis for neutrophils and T cells.
claimInterferon-alpha (IFN-α) is a pro-inflammatory cytokine produced by macrophages, neutrophils, and some somatic cells that binds to CD118 (IFNAR1, IFNAR2) and functions as an anti-viral agent.
referenceIL-17 is classified as a pro-inflammatory cytokine, is produced by Th17 cells, binds to the IL-17R receptor, targets monocytes and neutrophils, and functions in recruiting monocytes and neutrophils to the site of infection and activating downstream cytokines and chemokines including IL-1, IL-6, IL-8, IL-21, TNF-beta, and MCP-1.
Integrating allostasis and emerging technologies to study complex ... nature.com 1 fact
claimStress stimulates the proliferation of neutrophils and macrophages and induces the release of pro-inflammatory cytokines and chemokines.
Homeostatic medicine: a strategy for exploring health and disease link.springer.com 1 fact
procedureIn the immune response to SARS-CoV-2, infected cells are recognized by macrophages and dendritic cells, which triggers macrophages to produce proinflammatory cytokines and chemokines, leading to the recruitment of inflammatory cells like neutrophils to the infection site.