Knowledge Tree
Relations (1)
related 0.30 — supporting 3 facts
Dendritic cells initiate inflammation as innate immune cells using PRRs to recognize harmful stimuli [1], secrete cytokines and chemokines that activate leukocytes to release inflammation mediators [2], and produce the pro-inflammatory cytokine IL-1 involved in inflammation [3].
Facts (3)
Sources
The Role of Immune Cells in Inflammation jmolpat.com 1 fact
claimInnate immune cells, specifically macrophages, dendritic cells, and neutrophils, initiate the pathophysiological processes of inflammation by using Pattern Recognition Receptors (PRRs) to recognize harmful stimuli.
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 1 fact
referenceIL-1 is classified as a pro-inflammatory cytokine, is produced by macrophages, B cells, and dendritic cells, binds to the CD121a receptor, targets B cells, NK cells, and T cells, and functions in pyrogenic activity, inflammation, cell proliferation, differentiation, and bone marrow cell proliferation.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 1 fact
claimOnce circulating leukocytes enter a local injury site, they are activated by cytokines and chemokines secreted by macrophages and dendritic cells, subsequently releasing their own cytokines and mediators of inflammation.