neurodegeneration ↔ aging

Relations (1)

related 2.32 — strongly supporting 4 facts

Aging and neurodegeneration are intrinsically linked through shared biological mechanisms such as sleep microstructure changes [1], lipid assembly dynamics [2], inflammatory and circadian processes [3], and metabolic regulation involving NAD+ levels [4].

Facts (4)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature 2 facts

referenceMontaruli et al. (2020) published 'The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration' in Neurobiology of Disease, examining the intersection of aging, inflammation, and circadian rhythms in neurodegenerative conditions.

referenceLipid assemblies are at the intersection of aging, proteostasis, and neurodegeneration, as described in the 2019 paper 'Lipid assemblies at the crossroads of aging, proteostasis, and neurodegeneration' published in Trends in Cell Biology.

Sleep Across the Lifespan: A Neurobehavioral Perspective link.springer.com Springer 1 fact

referenceAndré et al. demonstrated that changes in REM sleep microstructure are related to greater neurodegeneration and amyloid deposition in aging.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 1 fact

referenceNAD+ levels are implicated in aging, metabolism, and neurodegeneration, as detailed by E. Verdin in a 2015 article in Science.