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Inflammation is linked to Major Depressive Disorder through the social signal transduction theory of depression, which explicitly connects stress to both inflammation and MDD [1], and via established associations between stress, sex hormones, inflammation, and MDD [2].
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Chronic inflammation in the etiology of disease across the life span nature.com 1 fact
claimStress, sex hormones, and inflammation are linked to major depressive disorder, and the social signal transduction theory of depression can be extended to account for sex differences in mood disorders, as proposed by Slavich and Sacher in 2019.
Chronic inflammation in the etiology of disease across the life span academia.edu 1 fact
referenceG. M. Slavich and M. R. Irwin developed a social signal transduction theory of depression, linking stress to inflammation and major depressive disorder, published in Psychological Bulletin in 2014.