Allostatic load ↔ chronic stress

Relations (1)

related 3.32 — strongly supporting 9 facts

Allostatic load is defined as the cumulative physiological wear and tear on the body resulting from chronic stress [1], [2], and it serves as a unifying mechanism explaining how chronic stress leads to various health pathologies [3], [4].

Facts (9)

Sources

Integrating allostasis and emerging technologies to study complex ... nature.com Nature 3 facts

referenceStabellini, N. et al. (2024) investigated the relationship between allostatic load/chronic stress and cardiovascular outcomes in patients diagnosed with breast, lung, or colorectal cancer, published in the Journal of the American Heart Association.

claimAllostatic load is defined as the cumulative physiological burden imposed on the body by chronic stressors, including persistent psychosocial pressure, drug abuse, and chronic infections.

referenceJuster, R. P., McEwen, B. S. & Lupien, S. J. (2010) reviewed allostatic load biomarkers of chronic stress and their impact on health and cognition in Neuroscience & Biobehavioral Reviews.

Understanding Allostasis: Stability Through Change - Cannelevate cannelevate.com.au CannElevate 2 facts

claimAllostatic load serves as a unifying mechanism that explains why chronic stress is linked to elevated risks for cardiovascular disease, diabetes, depression, and cognitive decline.

claimIndividuals can experience high allostatic load without subjectively feeling stressed, as they may habituate to chronic stress or experience physiological dysregulation without conscious awareness.

Homeostasis vs. Allostasis: Why Your Body Needs More Than Stability trueself.health TrueSelf Health 2 facts

claimAllostatic load is the cumulative physiological wear and tear on the nervous system and body systems, such as the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system, resulting from chronic stress, overpreparation, or misaligned physiological predictions.

claimAllostatic load is the cumulative physiological wear and tear on the nervous system and body systems, such as the hypothalamic-pituitary-adrenal axis and sympathetic nervous system, resulting from chronic stress, overpreparation, or misaligned predictions.

Allostasis revisited: A perception, variation, and risk framework frontiersin.org Frontiers 2 facts

claimThe definition of allostatic load developed by Bruce McEwen and Stellar (1993) and elaborated by Bruce McEwen (1998) refers to specific pathologies associated with chronic stress, particularly chronic exposure to elevated glucocorticoid hormones in humans and laboratory animals.

claimJuster and McEwen (2015) propose new directions for allostatic load research in the context of sleep and chronic stress.