Knowledge Tree
Relations (1)
related 2.32 — strongly supporting 4 facts
Allostatic load is identified as a unifying mechanism that explains the elevated risk of developing depression due to chronic stress exposure, as noted in [1] and [2]. Furthermore, [3] highlights that dysregulation associated with allostatic load is a critical factor in the etiology of depression, often overlooked in favor of genetic explanations.
Facts (4)
Sources
Understanding Allostasis: Stability Through Change - Cannelevate cannelevate.com.au 2 facts
claimAllostatic load serves as a unifying mechanism that explains why chronic stress is linked to elevated risks for cardiovascular disease, diabetes, depression, and cognitive decline.
claimAllostatic load serves as the unifying mechanism explaining why individuals experiencing chronic stress face elevated risks for cardiovascular disease, diabetes, depression, and cognitive decline.
Homeostasis vs Allostasis — The Urban Health Council urbanhealthcouncil.com 1 fact
perspectiveThe lack of standardized definitions for allostatic load (AL) and allostatic overload (AOL) leads many studies to incorrectly identify genetic makeup as the leading cause for complex diseases like depression, rather than dysregulation from chronic stress exposure.
Integrating allostasis and emerging technologies to study complex ... nature.com 1 fact
referenceThe source cites several key works on stress neurobiology and allostasis, including Godoy et al. (2018) on stress neurobiology, Cannon (1929) on physiological homeostasis, Azmi et al. (2021) on cortisol and circadian rhythm, Sterling and Eyer (1988) on allostasis and arousal pathology, McEwen and Wingfield (2003) on allostasis in biology, Chodkiewicz (2023) on addiction memory and allostasis, George et al. (2012) and Koob and Le Moal (2001) on allostasis and addiction, Savransky et al. (2018) on allostatic load in schizophrenia, and Honkalampi et al. (2021) on allostatic load in depression.