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Psilocybin is related to mood because it calms brain circuits tied to pain and mood by working in the anterior cingulate cortex, easing emotional distress as demonstrated in [1].

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Psychedelic Drugs News - ScienceDaily sciencedaily.com ScienceDaily 1 fact
claimUniversity of Pennsylvania researchers found that psilocybin can calm brain circuits tied to pain and mood by working in the anterior cingulate cortex, which eases both physical suffering and emotional distress in animal studies.