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Psilocybin and MDMA are both classified as psychedelics that impact episodic memory processes as noted in [1], and their effects on resting state functional connectivity were jointly investigated in a study published in Frontiers in Human Neuroscience [2].
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Neuroimaging in psychedelic drug development: past, present, and ... nature.com 6 facts
claimResting-state data from neuroscience studies has provided insights into the acute brain-network effects of psilocybin, LSD, and MDMA.
claimWhile the authors focused their study outlines on 5-HT2AR agonist 'classic' psychedelics like psilocybin, LSD, and DMT, these study frameworks could be applied to other novel therapies such as ketamine, MDMA, and ibogaine.
measurementAs of the time of writing, there are 96 registered clinical trials for psilocybin, 112 for MDMA, 132 for LSD, 20 for Dimethyltryptamine, and 4 for ibogaine listed on clinicaltrials.gov.
referenceA systematic review published in Psychopharmacology in 2022 examined drug-drug interactions between psychiatric medications and MDMA or psilocybin.
claimTask fMRI data has shown that LSD affects the brain's response to positive hedonic stimuli such as music, psilocybin affects social and emotional processing, and MDMA affects the recall of positive and negative emotional memories.
claimModern research into classic psychedelics and related compounds includes the study of LSD, psilocybin, N,N-Dimethyltryptamine (DMT), MDMA, ketamine, and ibogaine.
Ancient Roots of Today's Emerging Renaissance in ... link.springer.com 2 facts
claimIn the last decade, governing bodies have approved clinical trials for MDMA, ketamine, LSD, psilocybin, and dimethyltryptamine.
claimInterventions using psilocybin and MDMA have been most effective when carried out over several weeks with oversight from therapists, according to studies by Carhart-Harris et al. (2021), Davis et al. (2020), Griffiths et al. (2016), and Mitchell et al. (2021).
Psychedelics, Sociality, and Human Evolution frontiersin.org 2 facts
referenceThe study 'Psilocybin and MDMA reduce costly punishment in the Ultimatum Game', published in 2018 in Scientific Reports by A. S. Gabay et al., demonstrates that psilocybin and MDMA influence behavior in the Ultimatum Game by reducing costly punishment.
referenceDe Gregorio et al. (2021a) reviewed preclinical and clinical studies on the use of hallucinogens, specifically LSD, psilocybin, MDMA, and ketamine, in mental health, published in the Journal of Neuroscience.
Psychedelics and Consciousness: Distinctions, Demarcations, and ... ouci.dntb.gov.ua 2 facts
claimSedatives (alcohol, zolpidem, triazolam), dissociatives (ketamine, dextromethorphan), psychedelics (psilocybin, MDMA), stimulants (dextroamphetamine, dextromethamphetamine), and cannabinoids (THC) each have idiosyncratic effects on episodic memory, differentially impairing certain mnemonic processes while sparing or facilitating others.
claimLeor Roseman et al. studied the effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers, published in Frontiers in Human Neuroscience, volume 8, page 204.
What Western medicine can learn from the ancient history of ... - BBC bbc.com 2 facts
claimProponents of psychedelic-assisted therapy suggest that compounds like MDMA, LSD, psilocybin, and ketamine may help alter the perspectives of individuals suffering from 'diseases of despair'—such as suicide, drug overdose, and alcohol abuse—when used in conjunction with talking therapy.
claimModern medical researchers are investigating psychedelic compounds such as MDMA, LSD, psilocybin, and ketamine as potential treatments for psychiatric disorders including anxiety, depression, and substance abuse.
history Archives - UC Berkeley Center for the Science of Psychedelics psychedelics.berkeley.edu 1 fact
perspectiveIn a February 2014 editorial, Scientific American called for an end to the ban on psychedelic drug research, criticizing the mental health treatment industry for a lack of progress since the 1950s and arguing that regulators have unfairly prohibited drugs like LSD, MDMA, and psilocybin.
Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org 1 fact
referenceA 2024 study published in Scientific Reports by Sharma et al. investigated the knowledge, attitudes, and concerns of U.S. healthcare professionals regarding psilocybin and MDMA as novel therapies.
The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org 1 fact
claimWhile some experts define the term 'psychedelic' specifically as agonists of serotonin 2A receptors (such as psilocybin), psychedelic treatment models have been applied to diverse psychoactive drugs including MDMA, ibogaine, cannabis, and ketamine.
The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org 1 fact
referenceThe paper 'The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers' by L. Roseman, R. Leech, A. Feilding, D. Nutt, and R. Carhart-Harris, published in Frontiers in Human Neuroscience in 2014, investigates the neurological impact of psilocybin and MDMA.