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Psilocybin is related to the cortex because classic psychedelics, including psilocybin, exert their primary effects through the serotonin 2A (5-HT2A) receptor, which is heavily expressed throughout the cortex [1].

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Ancient Roots of Today's Emerging Renaissance in ... link.springer.com Springer 1 fact
claimClassic psychedelics, including psilocybin, LSD, and ayahuasca, exert their primary effects through the serotonin 2A (5-HT2A) receptor, which is heavily expressed throughout the cortex.