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Psilocybin treatment has been shown to reduce glutamate concentrations in the anterior cingulate cortex as measured by MRS [1], and research by Mason et al. specifically links psilocybin-induced ego dissolution to regional alterations in glutamate levels {fact:2, fact:3}.

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Neuroimaging in psychedelic drug development: past, present, and ... nature.com Nature 1 fact

measurementAn open-label study of patients with major depressive disorder reported reductions in glutamate and N-Acetylaspartate concentrations in the anterior cingulate cortex, as measured by Magnetic Resonance Spectroscopy (MRS), following psilocybin treatment.

Psychedelics and Consciousness: Distinctions, Demarcations, and ... ouci.dntb.gov.ua David B Yaden, Matthew W Johnson, Roland R Griffiths, Manoj K Doss, Albert Garcia-Romeu, Sandeep Nayak, Natalie Gukasyan, Brian N Mathur, Frederick S Barrett · Oxford University Press 1 fact

referenceMason reported on regional alterations in glutamate and the experience of ego dissolution associated with psilocybin, published in Neuropsychopharmacology (Volume 45, page 2003).

Altered State of Consciousness | Springer Nature Link link.springer.com Springer 1 fact

referenceThe study 'Me, myself, bye: Regional alterations in glutamate and the experience of ego dissolution with psilocybin' was published in the journal Neuropsychopharmacology in 2020.