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related 2.32 — strongly supporting 7 facts

Aging and obesity are linked as interconnected physiological processes that share common pathological pathways, such as T cell immunosenescence [1] and white adipose tissue dysfunction [2]. They are frequently studied together as parallel contributors to health decline [3] and are both recognized as significant risk factors for cardiovascular disorders [4].

Facts (7)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature 2 facts

referenceShirakawa and Sano reviewed T cell immunosenescence in the context of aging, obesity, and cardiovascular disease in the journal Cells in 2021.

referenceTam, Morais, and Santosa (2020) discussed the relationship between obesity and aging, characterizing them as two sides of the same coin.

Chronic inflammation in the etiology of disease across the life span nature.com Nature 2 facts

referenceAging and obesity share biological hallmarks related to dysfunctional adipose tissue, a concept termed 'adipaging', as described in a 2016 study in the Journal of Physiology.

referenceAging and obesity are linked to inflammatory age-related diseases, as detailed in a 2017 study in Frontiers in Immunology.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 1 fact

referenceReyes-Farias M. et al. published 'White adipose tissue dysfunction in obesity and aging' in Biochemical Pharmacology in 2021, discussing adipose tissue changes.

The New Field of Network Physiology: Building the Human ... frontiersin.org Frontiers 1 fact

claimNetwork Physiology research investigates the pairwise and network interactions of organ systems and sub-systems, and how these interactions manifest in aging, exercise, sports, and various clinical conditions such as concussion, traumatic brain injury, cardiac arrest, sleep and neurodegenerative disorders, diabetes, obesity, maternal-fetal and neonatal care, sepsis, coma, and multiple organ failure.

Stress, Lifestyle, and Health – Introduction to Psychology open.maricopa.edu Maricopa Open Digital Press 1 fact

claimRisk factors for cardiovascular disorders include social determinants (aging, income, education, employment status), behavioral factors (unhealthy diet, tobacco use, physical inactivity, excessive alcohol consumption), and medical conditions (obesity, diabetes).