Knowledge Tree
Relations (1)
related 3.32 — strongly supporting 5 facts
Cellular senescence is a fundamental biological process that acts as a driver and marker of aging, as evidenced by its role in tissue degeneration [1], chronic inflammation [2], and age-related diseases {fact:2, fact:8}. The accumulation of senescent cells is widely recognized as a critical factor contributing to the aging process {fact:1, fact:4, fact:5, fact:7, fact:9}.
Facts (5)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com 3 facts
referenceInflammation, epigenetics, and metabolism converge to influence cell senescence and aging, as described by Zhu et al. in a 2021 Signal Transduction and Targeted Therapy paper.
referenceCellular senescence and its potential role in tumor promotion and aging are examined in the 2016 paper 'Cellular senescence and tumor promotion: Is aging the key?' published in Biochimica et Biophysica Acta.
referenceLiu, R. M. discusses aging, cellular senescence, and Alzheimer’s disease in the International Journal of Molecular Sciences.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 1 fact
claimThe article "Cellular senescence: from homeostasis to pathological implications and therapeutic strategies" addresses the topics of cellular senescence, cancer, m6A RNA methylation, aging, longevity, and inflammation.
Chronic inflammation in the etiology of disease across the life span nature.com 1 fact
claimCellular senescence is a factor in aging and cancer, as detailed in a 2013 review in the Annual Review of Physiology.