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Relations (1)
related 8.00 — strongly supporting 8 facts
Ketamine is linked to neurogenesis through its ability to modulate neural plasticity, where it promotes synaptogenesis and neuron formation in single-dose paradigms {fact:1, fact:3, fact:6}, while high-dose or neonatal exposure can conversely disrupt these processes {fact:2, fact:6, fact:7}.
Facts (8)
Sources
Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com 8 facts
claimKetamine exhibits a dual profile regarding neurogenesis and neural plasticity: it promotes synaptogenesis, neurite growth, and new neuron formation in single-dose paradigms, but high doses or neonatal exposure are linked to neurogenesis impairment and long-term cognitive deficits.
claimHuang et al. (2016) reported that ketamine affects the neurogenesis of the hippocampal dentate gyrus in 7-day-old rats.
claimThe metabolite 2R,6R-HNK may contribute to the positive effects of ketamine on neurogenesis through the upregulation of brain-derived neurotrophic factor (BDNF).
claimA rat model of schizophrenia using ketamine showed increased neurogenesis.
claimSerotonin can promote neurogenesis independently of BDNF, implying that ketamine's influence on neurogenesis may involve the modulation of serotonergic pathways.
claimKetamine generally enhances neurogenesis and synaptic plasticity in adult subjects, which contrasts with the effects of high-dose ketamine in neonatal animals.
claimKetamine increases BDNF levels, which promotes synaptogenesis, neurite growth, and neurogenesis.
claimEarly high-dose ketamine exposure can disrupt neurogenesis during critical developmental periods, leading to lasting cognitive impairments, potentially mediated by alterations in BDNF signaling.