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- Canales and Ferrer-Donato (2014) demonstrated that a 10 mg/kg dose of MDMA combined with alcohol, administered during the E13-E15 pregnancy window, reduced neurogenesis (proliferation and survival) by approximately 40% in adult female offspring compared to saline controls.
- Prenatal and neonatal exposure to MDMA can result in long-term impairments in neurogenesis and behavioral deficits.
- García-Cabrerizo and García-Fuster (2016) found no significant impact on neurogenesis in rats when a lower dosage of 15 mg/kg of MDMA (3 × 5 mg within 1 day) was administered.
- MDMA exhibits dose-dependent effects on neurogenesis, where high doses are linked to decreased proliferation and survival of new neurons, potentially leading to neurotoxic outcomes.
- Cho et al. (2008) investigated the impact of MDMA on adult neurogenesis in the offspring of dams exposed to 1.25 or 20 mg/kg of MDMA for 36 days (E6-P21) via oral gavage.
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Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com 5 facts
measurementCanales and Ferrer-Donato (2014) demonstrated that a 10 mg/kg dose of MDMA combined with alcohol, administered during the E13-E15 pregnancy window, reduced neurogenesis (proliferation and survival) by approximately 40% in adult female offspring compared to saline controls.
claimPrenatal and neonatal exposure to MDMA can result in long-term impairments in neurogenesis and behavioral deficits.
measurementGarcía-Cabrerizo and García-Fuster (2016) found no significant impact on neurogenesis in rats when a lower dosage of 15 mg/kg of MDMA (3 × 5 mg within 1 day) was administered.
claimMDMA exhibits dose-dependent effects on neurogenesis, where high doses are linked to decreased proliferation and survival of new neurons, potentially leading to neurotoxic outcomes.
procedureCho et al. (2008) investigated the impact of MDMA on adult neurogenesis in the offspring of dams exposed to 1.25 or 20 mg/kg of MDMA for 36 days (E6-P21) via oral gavage.