Knowledge Tree
Relations (1)
related 3.00 — strongly supporting 7 facts
Allostatic load and glucocorticoids are linked as key concepts in the energetics-based framework of stress response [1], where glucocorticoid levels are predicted to change in parallel with allostatic load [2]. Furthermore, glucocorticoids are implicated in managing the energetic demands that define allostatic load [3], and chronic allostatic overload is specifically associated with pathologically elevated glucocorticoid levels [4].
Facts (7)
Sources
Allostasis revisited: A perception, variation, and risk framework frontiersin.org 7 facts
claimIn the energetics-based framework for allostatic load, Type II allostatic overload occurs when allostatic load remains high without exceeding basal energy available, resulting in pathology associated with chronically elevated glucocorticoids.
claimGlucocorticoids are implicated in processes related to energy balance, which determines responses to energetic demand (allostatic load) and influences subsequent physiology and behavior associated with coping.
claimGlucocorticoid levels are predicted to change in parallel with allostatic load.
claimThe Perceived Resource Potential (PRP) describes the gap between allostatic load (Eload) and resource availability (Ecr), and is proposed to correlate with glucocorticoid levels rather than allostatic load itself.
claimStrategy 1 for endocrine response involves glucocorticoids gradually elevating in direct inverse correlation with the difference between allostatic load and resource availability (PRP) when PRP is low, reaching the ELHS activation threshold only when PRP equals zero.
claimMcEwen and Wingfield (2010) argued that the suppression of glucocorticoids during Phase II starvation challenges the relevance of starvation as a defining factor for allostatic load.
claimThe article 'Allostasis revisited: A perception, variation, and risk framework' identifies allostasis, allostatic load, perturbation resistance potential, glucocorticoid, and environment as key concepts.