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Relations (1)
related 3.32 — strongly supporting 9 facts
Testosterone and prolactin are both key hormones investigated in the context of human hormonal health, seasonality, and aging, as evidenced by their frequent co-measurement in clinical studies [1], [2], [3], and [4]. They are also linked through their shared physiological roles, such as the inhibition of GnRH secretion [5] and their observed variations in patients with hypogonadism [6] and prepubertal males [7].
Facts (9)
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Seasonal Changes of Serum Gonadotropins and Testosterone in ... frontiersin.org 6 facts
measurementThe laboratory reference ranges used in the study were 2.2–8.7 ng/dL for testosterone, 1–9 IU/L for LH, 1–12 IU/L for FSH, and 3–13 ng/mL for PRL.
claimProlactin (PRL) serum levels in adult human males do not correlate with testosterone (Rho: 0.002, p = 0.804), luteinizing hormone (Rho: 0.005, p = 0.665), or follicle-stimulating hormone (Rho: 0.006, p = 0.734).
referencePatients with primary and secondary hypogonadism exhibit seasonal variations in plasma gonadotropin, prolactin, and testosterone levels, suggesting an independent testicular role in these variations, according to Bellastella et al. (2013).
claimGonadotropins, testosterone, and prolactin are the most investigated hormones for detecting the potential persistence of hormone seasonality in humans.
referencePrepubertal males exhibit circannual rhythms of plasma luteinizing hormone, follicle-stimulating hormone, testosterone, prolactin, and cortisol, according to a 1983 study by Bellastella et al.
referenceMaes et al. (1997) analyzed components of biological variation, including seasonality, in blood concentrations of TSH, TT3, FT4, PRL, cortisol, and testosterone in healthy volunteers.
“Manopause”: How Male Hormones Change With Age - JCMC jcmchealth.com 1 fact
claimAs men age, they naturally experience a decrease in growth hormone (GH), prolactin, and insulin-like growth factor-1 (IGF-1) in addition to testosterone.
Understanding Male Hormonal Changes: A Complete Guide (2025) coremedicalwellness.com 1 fact
claimBlood tests for male hormonal health typically measure total and free testosterone, thyroid hormones (TSH, T3, and T4), and other hormones such as LH, FSH, prolactin, DHEA, and cortisol.
Physiology, Male Reproductive System - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 1 fact
claimThe secretion of GnRH is inhibited by testosterone, estrogen, estradiol, and prolactin.