Knowledge Tree
spleen
Facts (16)
Sources
Parts of the Immune System | Children's Hospital of Philadelphia chop.edu 6 facts
claimPeople who have had a splenectomy (removal of the spleen) are at a greater risk of suffering from bacterial infections like meningococcus and pneumococcus, making it important for them to stay up to date on relevant vaccines.
claimThe spleen is the largest internal organ of the immune system and contains a large number of immune system cells.
measurementApproximately 25 percent of the blood that comes from the heart flows through the spleen on every beat.
claimThe spleen is particularly important in protecting people from bacterial infections such as meningococcus and pneumococcus.
claimOrgans and tissues essential to the immune system include the thymus, bone marrow, lymph nodes, lymph vessels, spleen, and skin.
claimThe spleen filters circulating blood to detect pathogens, which triggers the activation and multiplication of immune system cells to neutralize those pathogens.
The components of the immune system - Immunobiology - NCBI - NIH ncbi.nlm.nih.gov 6 facts
referenceIn the spleen, lymphocytes surround the arterioles to form white pulp, which is divided into a periarteriolar lymphoid sheath (PALS) containing mainly T cells, and a flanking B-cell corona.
referenceThe spleen is a fist-sized organ located behind the stomach that collects antigen from the blood and disposes of senescent red blood cells.
referenceThe bulk of the spleen is composed of red pulp, which serves as the site of red blood cell disposal.
claimThe peripheral lymphoid organs, which include the lymph nodes, the spleen, and the mucosal lymphoid tissues, are the sites where antigen and lymphocytes encounter each other.
claimThe three major types of peripheral lymphoid tissue are the spleen (which collects antigens from blood), lymph nodes (which collect antigen from infection sites in tissues), and mucosal-associated lymphoid tissues (MALT) (which collect antigens from epithelial surfaces).
procedureNaive lymphocytes circulate continually from the blood into peripheral lymphoid tissues by squeezing between capillary wall cells, and return to the blood via lymphatic vessels or directly from the spleen.
The immune system and primary immunodeficiency primaryimmune.org 4 facts
claimMature T cells leave the thymus as naïve T cells and populate organs such as the spleen, lymph nodes, bone marrow, and blood, where they may become memory T cells after antigen exposure.
claimMonocytes line the walls of blood vessels in organs like the liver and spleen to capture microorganisms passing through the blood.
claimPlasma cells are the mature form of B cells that produce antibodies and are located in the spleen and lymph nodes.
claimMature B cells are located in the bone marrow, lymph nodes, spleen, some areas of the intestine, and the bloodstream.