Knowledge Tree
liver
Facts (9)
Sources
3. The Innate Immune System - Immunopaedia immunopaedia.org.za 4 facts
claimNatural killer (NK) cells are large granular lymphocytes derived from bone marrow precursors that are found mainly in peripheral circulation (5 to 20 percent of total lymphocytes), spleen, liver, and bone marrow.
claimTissue macrophages have specific names based on location: Kupffer cells (liver), histiocytes (connective tissues), mesangial cells (kidneys), osteoclasts and chondroclasts (bones and cartilage), alveolar macrophages (lungs), and microglial cells (brain).
claimCytokines produced by macrophages have systemic effects: IL-1 induces fever, TNF-alpha causes wasting (cachexia), IL-6 induces liver production of acute phase proteins, and IL-3 increases neutrophil maturation and release from bone marrow.
claimInvariant NKT (iNKT) cells are located in internal organs, specifically the thymus, bone marrow, liver, and spleen.
How the Immune System Works with Primary Immunodeficiency igcares.com 2 facts
claimThe liver is responsible for synthesizing proteins of the complement system and contains phagocytic cells that ingest bacteria from the blood.
claimThe complement system is composed of 30 blood proteins that function in an ordered fashion to defend against infection, with most of these proteins produced in the liver.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 1 fact
claimCytokines secreted by immune cells during the early stages of inflammation stimulate the liver to synthesize acute-phase proteins.
Rusty Gage, PhD - Salk Institute salk.edu 1 fact
claimLentiviral vectors can achieve sustained expression of genes when delivered directly into liver and muscle tissue, as demonstrated by Kafri, Blömer, Peterson, Gage, and Verma in 1997.
The immune system and primary immunodeficiency primaryimmune.org 1 fact
claimMonocytes line the walls of blood vessels in organs like the liver and spleen to capture microorganisms passing through the blood.