location

hippocampus

Facts (29)

Sources

Rusty Gage, PhD - Salk Institute salk.edu Salk Institute 26 facts

referenceA.M. Gonzalez, D.A. Lappi, M.L. Buscaglia, L.S. Carman, F.H. Gage, and A. Baird demonstrated that basic FGF-SAP mitotoxin has a specific lethal effect on cells expressing the basic FGF receptor in the hippocampus, as published in Progress in Clinical and Biological Research in 1991.

referenceO.G. Nilsson, M.L. Shapiro, F.H. Gage, D.S. Olton, and A. Björklund published 'Spatial learning and memory following fimbria-fornix transection and grafting of fetal septal neurons to the hippocampus' in Experimental Brain Research in 1987.

referenceF.H. Gage, G. Buzsaki, O. Nilsson, and A. Björklund published 'Grafts of fetal cholinergic neurons to the deafferented hippocampus' in Progress in Brain Research in 1987.

referenceH.W. Steinbusch, A. Beek, A.L. Frankhuyzen, J.A. Tonnaer, F.H. Gage, and A. Björklund published 'Functional activity of raphe neurons transplanted to the hippocampus and caudate-putamen. An immunohistochemical and neurochemical analysis in adult and aged rats' in the Annals of the New York Academy of Sciences in 1987.

referenceFagan, A.M. and Gage, F.H. proposed a role for IL-1 in cholinergic sprouting in the hippocampus, as published in Experimental Neurology (1990).

claimKesslak and Gage demonstrated the recovery of spatial alternation deficits following selective hippocampal destruction with kainic acid in a 1986 study.

referenceAdult-generated new neurons in the hippocampus of mice show early determination and long-term persistence, according to a 2003 study in the journal Development.

referenceF.H. Gage, A. Björklund, and U. Stenevi published 'Local regulation of compensatory noradrenergic hyperactivity in the partially denervated hippocampus' in Nature in 1983.

claimTransplanted septal neurons form viable cholinergic synapses with a host hippocampus, as demonstrated by Segal, Bjorklund, and Gage in 1985.

referenceH. Dickinson-Anson, I. Aubert, F.H. Gage, and L.J. Fisher authored the paper 'Hippocampal grafts of acetylcholine-producing cells are sufficient to improve behavioural performance following a unilateral fimbria-fornix lesion' published in Neuroscience in 1998 (Volume 84, Issue 3, pages 771-81).

referenceG. Acsádi, G. Buzsáki, T. Keszthelyi, L. Királyfalvi, and F.H. Gage studied the effects of confinement, previous experience, and hippocampal damage on the DRL (Differential Reinforcement of Low rates) schedule, as published in Behavioural Brain Research in 1986.

referenceA 2004 study in the Journal of Neuroscience by Lein, Zhao, and Gage defined a molecular atlas of the hippocampus using DNA microarrays and high-throughput in situ hybridization.

claimSelective denervation of the hippocampus enhances graft survival in the hippocampus, as reported by Gage and Björklund in 1986.

referenceKelly, Gage, Ingvar, Lindvall, Stenevi, and Björklund demonstrated the functional reactivation of the deafferented hippocampus by embryonic septal grafts, assessed by measuring local glucose utilization, in a 1985 Neuroscience Letters publication.

referenceG.A. Foster, M. Schultzberg, F.H. Gage, A. Björklund, T. Hökfelt, A.C. Cuello, A.A. Verhofstad, T.J. Visser, and P.C. Emson examined the transmitter expression and morphological development of embryonic medullary and mesencephalic raphé neurones after transplantation to the adult rat central nervous system, specifically grafts to the hippocampus, in a 1988 study published in Experimental Brain Research.

claimIntrahippocampal septal grafts form cholinergic synapses in the host hippocampus, as revealed by choline acetyltransferase immunocytochemistry in a 1986 study by Clarke, Gage, and Björklund.

referenceP.S. Eriksson, E. Perfilieva, T. Björk-Eriksson, A.M. Alborn, C. Nordborg, D.A. Peterson, and Rusty Gage provided evidence of neurogenesis in the adult human hippocampus, as published in the 1998 Nature Medicine.

referenceF.H. Gage, G. Buzsáki, and D.M. Armstrong documented NGF-dependent sprouting and regeneration in the hippocampus in a 1990 Progress in Brain Research publication.

referenceG. Buzsáki, F.H. Gage, J. Czopf, and A. Björklund demonstrated that fetal CNS transplants can restore rhythmic slow activity (theta) in the subcortically denervated hippocampus, as published in Brain Research in 1987.

referenceSuhonen, J.O., Peterson, D.A., Ray, J., and Gage, F.H. demonstrated that adult hippocampus-derived progenitors can differentiate into olfactory neurons in vivo in a 1996 study.

referenceJ.P. Kesslak, C.J. Frederickson, and F.H. Gage published 'Quantification of hippocampal noradrenaline and zinc changes after selective cell destruction' in Experimental Brain Research in 1987.

referenceS.B. Dunnett, F.H. Gage, A. Björklund, U. Stenevi, W.C. Low, and S.D. Iversen published 'Hippocampal deafferentation: transplant-derived reinnervation and functional recovery' in Acta psychiatrica Scandinavica. Supplementum in 1984.

referenceMechanisms of sprouting in the adult central nervous system involve cellular responses in areas of terminal degeneration and reinnervation in the rat hippocampus, as described by Holtzman, D.M., Li, Y., Chen, K., Gage, F.H., Epstein, C.J., and Mobley, W.C. in 1994.

referenceC.W. Shults, P. Johnston, and F.H. Gage compared substance K-like and substance P-like fibers and cells in the rat hippocampus in a 1987 paper published in Brain Research.

referenceBlaker, S.N., Armstrong, D.M., and Gage, F.H. studied the response of cholinergic neurons within the rat hippocampus to fimbria-fornix transection.

referenceHippocampal deafferentation results in axonal regeneration and limited functional recovery, according to a 1995 study published in the Journal of Comparative Neurology.

Physiology, Sleep Stages - StatPearls - NCBI Bookshelf - NIH ncbi.nlm.nih.gov National Library of Medicine 1 fact

claimThe hippocampus is a memory region that remains active during dreaming.

(PDF) Physiology and Neurobiology of Stress and Adaptation academia.edu Academia.edu 1 fact

referenceVan Praag H et al. found that exercise enhances learning and hippocampal neurogenesis in aged mice in a 2005 study published in the Journal of Neuroscience.

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 1 fact

referenceLaplagne DA et al. demonstrated the functional convergence of neurons generated in the developing and adult hippocampus.