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Charles S. Grob
Also known as: Charles A. Grob, Charles Grob, Charles S. Grob
Facts (17)
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History and Current Status of Psychedelics and Entactogens ... - NCBI ncbi.nlm.nih.gov 15 facts
claimCharles Grob noted that unlike conventional psychopharmacologic compounds, which are typically administered daily for long periods, psychedelics are administered only once or a few times within the context of ongoing psychotherapy.
claimClassic hallucinogens, such as mescaline, psilocin, and LSD, primarily affect the serotonergic system and are primarily 5-HT2A receptor agonists, according to Charles Grob.
claimCharles Grob and colleagues conducted the first Phase 1 study of MDMA in the early 1990s to establish safety parameters.
claimStudies have indicated that psychedelics may be effective in treating chronic refractory obsessive-compulsive disorder (OCD), antisocial behavior, autism, depression, and profound reactive anxiety, such as the existential anxiety associated with terminal cancer, according to Charles Grob.
claimCharles Grob, a professor of psychiatry and pediatrics at the University of California, Los Angeles, School of Medicine, stated that understanding the history of psychedelics is helpful for understanding their potential future role in psychiatry.
claimNon-classic hallucinogens include MDMA (also known as ecstasy or molly), ketamine, and ibogaine, according to Charles Grob.
claimConventional psychopharmacologic agents are intended to ameliorate a pathological brain state and are not dependent on the patient’s attitude or insight, whereas psychedelics loosen defenses, facilitate insight, and may induce a mystical experience, according to Charles Grob.
claimCharles Grob stated that psychedelics have shown some of the best outcomes in the treatment of alcoholism, drug addiction, and PTSD.
quoteCharles Grob stated that as psychedelics became linked to the politically active counterculture, they "became more and more outside the realm of what our society could deal with."
claimMany hallucinogenic compounds were originally discovered in plants and have been used by Indigenous people since time immemorial, according to Charles Grob.
accountFollowing its synthesis in 1912, MDMA was "put on a back shelf and forgotten" due to the onset of World War I, according to Charles Grob.
accountClinical interest in MDMA resurfaced in the mid-1970s, but by the early 1980s it became popular as a club drug, leading to its scheduling as a controlled substance, according to Charles Grob.
claimCharles Grob described the psychedelic experience as feeling like a waking, lucid dream or a thematic vision that tells a story.
accountBy the mid-to-late 1960s, research into psychedelics unraveled as the substances moved from research settings into the broader culture and became associated with the politically active counterculture, according to Charles Grob.
claimCharles Grob categorized hallucinogens into classic and non-classic types.
Ancient Roots of Today's Emerging Renaissance in ... link.springer.com 1 fact
referenceCharles A. Grob, Alicia L. Danforth, Gurpreet S. Chopra, Marycie Hagerty, Charles R. McKay, Adam L. Halberstadt, and George R. Greer published the 'Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer' in the Archives of General Psychiatry in 2011.
Classification Schemes of Altered States of Consciousness - ORBi orbi.uliege.be 1 fact
referenceCharles S. Grob, R.E. Poland, L. Chang, and T. Ernst published a study on the psychobiologic effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans, focusing on methodological considerations and preliminary observations in 1995.