concept

tricarboxylic acid cycle

Also known as: TCA, TCA cycle

Facts (9)

Sources

Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org Genes & Development 7 facts

claimIntestinal stem cells (ISCs) that cannot oxidize glucose in the tricarboxylic acid (TCA) cycle exhibit enhanced proliferation and self-renewal.

referenceBlocking glucose entry into the tricarboxylic acid (TCA) cycle in epidermal stem cells promotes their differentiation (Goguet-Rubio et al. 2016; Baksh et al. 2020).

claimKetone bodies enter the tricarboxylic acid (TCA) cycle as acetyl-CoA, bypassing glucose oxidation, which is typically a major source of acetyl-CoA in cells, according to Shi and Tu (2015).

referenceBlocking glucose entry into the tricarboxylic acid (TCA) cycle in intestinal stem cells (ISCs) enhances their self-renewal (Schell et al. 2017; Bensard et al. 2020).

claimIn the fed state, direct glucose oxidation increases, but lactate oxidation remains the primary mechanism by which glucose feeds the tricarboxylic acid (TCA) cycle.

claimUnder fasting conditions in vivo, glucose feeds into the tricarboxylic acid (TCA) cycle by circulating lactate in all tissues except the brain, while glucose primarily feeds into glycolysis and the pentose phosphate pathway.

referenceBlocking glucose oxidation in the tricarboxylic acid (TCA) cycle triggers compensatory oxidation of other substrates, including fatty acids (FAs), which may link decreased glucose availability to enhanced fatty acid oxidation in stem cells during dietary interventions (Corton et al. 2004; Sikder et al. 2018; Steinhauser et al. 2018; Rosenbaum et al. 2019).

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 2 facts

claimCitrate is a tricarboxylic acid (TCA) cycle metabolite associated with epigenetic modulation; it can be exported from mitochondria and converted into acetyl-CoA by the enzyme ATP-citrate lyase (ACL).

claimMitochondrial metabolism influences stem cell fate regulation through metabolites generated in the tricarboxylic acid (TCA) cycle, which function as co-factors or substrates for chromatin-modifying enzymes.