Knowledge Tree
suicidality
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The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org 7 facts
claimA randomized controlled trial (RCT) investigating music with ketamine found that both music and non-music interventions were effective and tolerable in a patient population characterized by high rates of comorbidity, suicidality, and chronicity.
claimKetamine is considered a putative psychedelic with several advantages, including a long medical track record, efficacy in treating severe Treatment-Resistant Depression (TRD) and suicidality, treatment sessions that are approximately 75% shorter than other psychedelic therapies, minimal drug–drug interactions, and safety in patients with bipolar affective disorder 1.
claimExisting clinical trials for Psychedelic-Assisted Psychotherapy (PAP) often have limited external validity because they enroll only 3–6% of screened patients, typically excluding those with suicidality and comorbidity.
measurementThe Montreal team's IV ketamine service for Treatment-Resistant Depression (TRD) resulted in rapid improvements in depression and suicidality in approximately 50% of patients, with these effects generally fading within days or weeks of the last dose.
claimKetamine's rapid benefits against suicidality and the cognitive impairments of depression theoretically reduce obstacles to productive psychotherapy.
claimThe Montreal model for ketamine treatment excludes patients with active substance use due to potential iatrogenic harms, but does not exclude patients with personality disorders or acute suicidality, provided safety concerns are managed.
claimKetamine demonstrates safety and benefits in suboptimal real-world contexts, even without psychological support, and is effective for highly severe patients, including those with active suicidality and bipolar disorder.
Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org 3 facts
referenceCarbonaro, Barrett, Bradstreet, Johnson, MacLean, Jess, and Griffiths published research in the Journal of Psychopharmacology in 2015 regarding the relationship between psilocybin, psychological distress, and suicidality.
referenceHendricks, Johnson, and Griffiths published a study in the Journal of Psychopharmacology in 2015 finding that classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population.
referenceMathai, D. S., McCathern, A. G., Guzick, A. G., Schneider, S. C., Weinzimmer, S. A., Cepeda, S. L., Garcia-Romeu, A., and Storch, E. A. published 'Parental Attitudes Toward Use of Ketamine in Adolescent Mood Disorders and Suicidality' in the Journal of Child and Adolescent Psychopharmacology in 2021.
Altered states of consciousness – Knowledge and References taylorandfrancis.com 2 facts
accountA participant in a clinical trial for end-of-life distress died by suicide two weeks after receiving a subtherapeutic 1-mg dose of psilocybin, although treatment-emergent suicidality has not been reported in trials.
claimMost contemporary clinical trials of psychedelics have excluded participants with active suicidal ideation, with the exception of a small placebo-controlled randomized controlled trial of ayahuasca that demonstrated a larger reduction in suicidality compared to placebo.
Sleep Deprivation, Sleep Disorders, and Chronic Disease - CDC cdc.gov Aug 31, 2023 1 fact
claimGunderson J, McDaniel K, and DiBlanda A found an association between insufficient sleep, depressive symptoms, and suicidality among Florida high school students in a 2023 study published in Preventing Chronic Disease.