concept

stimulation frequency

Also known as: stimulation frequency, stimulation frequencies

Facts (11)

Sources

Branching morphology determines signal propagation dynamics in ... nature.com Nature Aug 21, 2017 11 facts

claimIn neurons, for stimulation frequencies higher than 440 Hz and axonal lengths greater than 0.42 cm, only a finite number of spikes propagate successfully before the signal becomes flat.

claimIn unbranched linear axons, the axonal length at which the transition occurs between fully propagating trains and trains with failures monotonically decreases as stimulation frequency increases.

measurementFor unbranched linear axons at stimulus frequencies greater than 300 Hz and lengths greater than 0.5 cm, the propagation pattern consists of a single spike followed by several failures.

claimFor stimulus frequencies lower than 50 Hz in branched axons, signal propagation is determined solely by the geometric ratio (GR) of the axon: the signal propagates uninterruptedly if the GR is less than 34.2, and fails otherwise.

measurementIn unbranched linear axons, stimulus frequencies greater than 146 Hz (based on parameters in Supplementary Table S1) cause propagation failures, resulting in modulated, fragmented spike trains.

measurementAt intermediate stimulus frequencies (51–146 Hz, based on parameters in Supplementary Table S1), branched axons exhibit symmetric firing patterns between daughter branches, even when the branching points are geometrically asymmetric.

claimThe response type of a linear axonal segment is a function of stimulation frequency, axon radius, and segment length.

procedureThe authors of the paper 'Branching morphology determines signal propagation dynamics in...' systematically study signal propagation in unbranched and branched axons by scanning stimulus frequencies and morphological parameters.

claimAt high stimulus frequencies, branched axons exhibit asymmetric firing patterns between daughter branches due to the combined effects of unbranched and branched behavior repertoires.

claimIn unbranched linear axons, action potential spike trains propagate without modification at low stimulus frequencies.

claimFor stimulus frequencies higher than 146 Hz in branched axons, some spikes fail to propagate in the mother branch before reaching the branching point.