Knowledge Tree
stemness
Facts (9)
Sources
Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org 4 facts
claimHigh-fat diets enhance stemness through enforcing self-renewal via microbiota-derived butyrate, while ketogenesis enhances stemness via β-OHB accumulation.
claimFasting increases PPAR-dependent fatty acid oxidation in intestinal stem cells (ISCs) to maintain stemness, according to Mihaylova et al. (2018).
claimKetogenesis promotes stemness in the small intestine of mice, though it remains to be determined if other tissue stem cell types respond similarly to organismal ketogenesis.
claimAmino acid availability and metabolism are known regulators of stemness, as established by studies from Shyh-Chang et al. (2013), Carey et al. (2015), Taya et al. (2016), Wang et al. (2019), and Baksh et al. (2020).
Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Apr 16, 2018 3 facts
claimStem cells regulate their transcriptional machinery in response to environmental stimuli to choose between maintaining stemness or exiting stemness, which leads to either differentiation or cell death.
claimThe preference for glycolysis over mitochondrial function is suggested to be a fundamental feature of stemness, independent of the proliferative state of the cells.
claimMitochondrial metabolism plays a role in maintaining stemness, alongside the importance of glycolysis.
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 1 fact
claimCancer cells acquire stemness and differentiate into cancer stem cells (CSCs) through epithelial-mesenchymal transition (EMT) and cell fusion, which is a crucial step in cancer development.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 1 fact
referenceNavas L.E. and Carnero A. published 'NAD(+) metabolism, stemness, the immune response, and cancer' in Signal Transduction and Targeted Therapy in 2021, exploring the intersection of NAD+ metabolism with stem cell function and immunity.