Knowledge Tree
St John's Wort
Also known as: Hypericum perforatum
Facts (15)
Sources
Active Plant Principles and Applications in Plant Medicine irispublishers.com May 2, 2024 5 facts
claimThe herbaceous species Hypericum perforatum (St. John’s wort) contains flavonoids, with rutoside being the most important constituent.
claimHypericin is the main component of St. John’s wort (Hypericum perforatum), characterized by a reddish-purple color, but it does not possess laxative-purgative effects.
claimRecognized therapeutic properties of St. John’s wort (Hypericum perforatum) extracts include antidepressant, antispasmodic, bile secretion stimulation, astringent, sedative, pain relief, and cicatrizing effects.
measurementHyperici herba, which represents the aerial part and flowering seeds of St. John’s wort (Hypericum perforatum), contains between 13% and 17% tannins in the dry plant product.
claimPlants containing furano-coumarins with skin-sensitizing properties include Achillea millefolium (mousetail), Hypericum perforatum (St. John’s wort), chamomile, and hawthorn.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 3 facts
claimSt. John’s Wort reduces the effectiveness of antiviral therapies and oral contraceptives due to its enzyme-inducing effects.
referenceBilia AR and do Céu Costa M (2021) report that the harmonization of medicinal plants and their preparations in the European market has failed, specifically citing the cases of St. John’s wort, valerian, ginkgo, ginseng, and green tea.
referenceSt. John’s Wort can trigger changes in drug metabolism, which leads to the decreased effectiveness of essential medications, according to Bose et al. (2021).
Medicinal plants: bioactive compounds, biological activities ... frontiersin.org 2 facts
claimHypericum perforatum (St. John’s wort), originating from Europe, Asia, and North Africa, demonstrated in vitro antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Klebsiella oxytoca, Klebsiella pneumoniae, and Staphylococcus aureus.
claimHypericin and flavonoids, bioactive compounds found in Hypericum perforatum (St John’s wort), are effective against the MDR microorganism Staphylococcus aureus.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... academia.edu 1 fact
referenceZhou, S., Chan, E., Pan, S.Q., Huang, M., & Lee, E. J. D. (2004) authored the paper 'Pharmacokinetic Interactions of Drugs with St John's Wort', published in the Journal of Psychopharmacology.
Advances in Pharmacognosy for Modern Drug Discovery and ... jbph.org 1 fact
referenceSt. John's wort is used as a treatment for major depression.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... ouci.dntb.gov.ua 1 fact
referenceSt John's Wort exhibits pharmacokinetic interactions with drugs, as detailed in a 2004 study by Zhou, S., Chan, E., Pan, S.Q., Huang, M., and Lee, E. J. D. published in the Journal of Psychopharmacology.
Medicinal Plants and their Traditional Uses - Open Access Pub openaccesspub.org 1 fact
measurementThe seven best-selling herbal medicines in the world during the last century include gingko ($150 million in large American markets), St. John's wort (Hypericum perforatum, $140 million), ginseng ($96 million), garlic ($84 million), echinacea ($70 million), saw palmetto ($32 million), and cava ($17 million).
Diagnosis and Management of Generalized Anxiety Disorder ... - AAFP aafp.org May 1, 2015 1 fact
claimSt. John's wort, tryptophan, 5-Hydroxytryptophan, and S-adenosyl-l-methionine should be used with caution in combination with selective serotonin reuptake inhibitors (SSRIs) because of the increased risk of serotonin syndrome.