Knowledge Tree
somatic cells
Also known as: somatic cell, human somatic cells
Facts (9)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 3 facts
claimExtracellular signaling molecules, including extracellular vesicles (EVs), neurotransmitters, growth factors, hormones, and cytokines, function as cues to transmit information to target somatic cells or adult stem cells.
claimPartial reprogramming can reduce the epigenetic age of cells without causing a loss of cell identity, suggesting that full reprogramming into induced pluripotent stem cells (iPSCs) is not required to reverse the aging of somatic cells.
referenceGill et al. (2022) published 'Chemical reprogramming of human somatic cells to pluripotent stem cells' in Nature, describing a method for chemical-based cellular reprogramming.
Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Apr 16, 2018 3 facts
claimWahlestedt et al. (2014) found that somatic cells with a heavy mitochondrial DNA mutational load produce induced pluripotent stem cells that exhibit distinct differentiation defects, as reported in 'Somatic cells with a heavy mitochondrial DNA mutational load render induced pluripotent stem cells with distinct differentiation defects' published in Stem Cells.
referenceProteome dynamics are highly coordinated during the reprogramming of somatic cells to pluripotency, as observed by Hansson et al. in Cell Reports in 2012.
claimCervantes et al. (2002) report that embryonic stem cells and somatic cells differ in their mutation frequency and type in the paper 'Embryonic stem cells and somatic cells differ in mutation frequency and type' published in the Proceedings of the National Academy of Sciences.
Bioelectricity - The Levin Lab drmichaellevin.org 1 fact
claimTransmembrane voltage potential of somatic cells controls oncogene-mediated tumorigenesis at long-range, according to a 2014 study by Chernet and Levin.
Integrating allostasis and emerging technologies to study complex ... nature.com Nov 5, 2025 1 fact
claimHuman induced pluripotent stem cells (iPSCs), which are reprogrammed from a patient’s somatic cells, allow for personalized research that captures a patient’s specific genetic background while avoiding the ethical concerns associated with embryonic stem cells.
A Copernican Approach to Brain Advancement: The Paradigm of ... frontiersin.org Apr 25, 2019 1 fact
claimElectron microscopic findings demonstrate the ubiquity of nerve fibers on blood vessels and endocrine cells, suggesting that the brain has close access to essentially every somatic cell.